WebDec 29, 2011 · Untreated HEp-2 cells (A) and cells treated with inhibitors 2 mM DON (CTPS inhibitor, B), 2 mM Acivicin (CTPS inhibitor, C), or 2 mM Ribavirin (IMPDH2 inhibitor, D) for 24 h were co-stained with human anti-RR serum It2006 (green) and rabbit anti-giantin (red). Nuclei were counterstained with DAPI (blue). WebJul 18, 2010 · CtpS is bifunctional, as the filaments it forms regulate the curvature of C. crescentus cells independently of its catalytic function.
Polarised maintenance of cytoophidia in Drosophila follicle …
WebCTPS inhibitors that arrest cancer cell proliferation (18-24) and are toxic to yeast and bacteria (18, 25). Moreover, using these inhibitors to deplete the intracellular CTP concentration increases the efficacy of the anticancer/antiviral drugs cytosine arabinoside (26, 27), 2′,3′-dideoxy-3′-thia- WebOct 20, 2024 · In this study, we transiently knockdown CTPS during the two to four-cell stage by way of ctps1a and ctps1b-specific morpholinos (MO). We also treated young embryos with the CTPS inhibitor drug DON in order to see whether disruption to the protein itself will bear similar effects on zebrafish development. razor hermosillo
STP938, a Selective CTPS1 Inhibitor, Shows Single Agent Activity …
WebJun 10, 2024 · Step Pharma, a world leader in CTPS1 inhibition for the targeted treatment of cancer, announces today that it is presenting encouraging data in three posters for its … WebOct 1, 2015 · Here, we show that IMPDH forms cytoophidia without inhibition of GTP synthesis. First, we find that an elevated intracellular CTP concentration or treatment with 3'-deazauridine, a CTPS inhibitor, promotes IMPDH cytoophidium formation and increases the intracellular GTP pool size. WebOct 5, 2024 · Selective inhibition of the proliferative CTPS1 isoform is therefore desirable in the treatment of immune disorders and lymphocyte cancers, but little is known about … razor heroclix