Web201 rows · CTNNB1 S37F lies within the ubiquitination recognition motif of the Ctnnb1 protein and occurs at a Gsk3b phosphorylation site on the Ctnnb1 protein (PMID: … WebJan 1, 2024 · DNA sequencing detected CTNNB1 point mutations in all 6 sequenced tumors: D32H, S33C, S33F, S37A, S37C, and S37F. RNA sequencing was negative for gene fusions in all 6 sequenced tumors. Clinical follow-up was available for 17 patients (74%; range: 4 mo to 20 y; median: 3.5 y), including 14 patients with >1 year of follow-up.
Non-small cell lung carcinomas with CTNNB1 (beta-catenin
WebJun 1, 2024 · The most frequent CTNNB1 exon 3 mutations were S37F (n = 8, 30.8%) and S45P (n = 5, 19.2%). Other were S33C (n = 3), G34R (n = 2), S37C (n = 2), D32H, … WebGene: CTNNB1 Variant: S37F: Impact List: missense: Protein Effect: gain of function: Gene Variant Descriptions: CTNNB1 S37F lies within the ubiquitination recognition motif of the … how many teaspoons are in 8 0z
Single-cell RNA sequencing highlights intratumor heterogeneity …
WebMay 16, 2024 · The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, … WebThis study characterizes the frequency of exon 3 CTNNB1 mutations and compares the expression of CTNNB1 transcript variants and downstream targets MYC and WAF1 (p21) across the neoplastic progression of esophageal squamous cell carcinomas (ESCCs). ... S37F in the SxxxS repeat region, and a germline polymorphism, T59A. Thus, mutation of … WebDescription: The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or … how many teaspoons are in 4 milliliters